منابع مشابه
Total synthesis of sulfolipid-1.
Sulfolipid-1, a tetra-acylated sulfotrehalose from Mycobacterium tuberculosis, was isolated over 40 years ago. Being a main component of the mycomembrane of M. tuberculosis, its biosynthesis and function have been studied in depth, but the chemical synthesis of sulfolipid-1 has not been reported. The synthesis presented here is based on iterative catalytic asymmetric conjugate additions of meth...
متن کاملComplete sulfolipid-1 biosynthesis in Mycobacterium tuberculosis 1 Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis*
From the Departments of Chemistry and Molecular and Cell Biology, and Howard Hughes Medical Institute University of California, Berkeley, CA 94720, the Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, the Department of Chemical Physiology, Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA 92037, and the Department of Microbio...
متن کاملTotal Synthesis of Taxol . 1
A successful strategy for the enantioselective synthesis of the natural stereoisomer of Taxol (1) has been developed. This strategy utilized the convergent assembly of Taxol's central eight-membered B ring from preformed synthons for rings A (10) and C (9) followed by late introduction of the D ring and side chain. Degradative studies conf i ied the viability of certain crucial manipulations in...
متن کامل1 Total synthesis of a 20 - deoxybryostatin
Chromatography was performed using Merck silica gel (60H; 40-60, 230-240 mesh). Petrol refers to light petroleum which was redistilled before use and refers to the fraction boiling between 40 and 60 °C. Tetrahydrofuran was dried over sodium-benzophenone and was distilled prior to use. Dichloromethane was dried over CaH2 and was distilled before use. Ether refers to diethyl ether. Reactions und...
متن کاملSulfolipid-1 Biosynthesis Restricts Mycobacterium tuberculosis Growth in Human Macrophages
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is a highly evolved human pathogen characterized by its formidable cell wall. Many unique lipids and glycolipids from the Mtb cell wall are thought to be virulence factors that mediate host-pathogen interactions. An intriguing example is Sulfolipid-1 (SL-1), a sulfated glycolipid that has been implicated in Mtb pathogenesis,...
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ژورنال
عنوان ژورنال: Chem. Commun.
سال: 2014
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c3cc48087a